Flutemide is coming into use as an antiandrogen with transgender women. It's reportedly a descent antiandrogen, however there are serious concerns with the liver for that particular drug.
Because I'm really interested in MtF HRT I'd like to share that bicalutamide is a another nonsteroidal antiandrogenin (in the same class as flutamide) which blocks T (as opposed to reducing it). However bicalutamide is significantly more potent than flutamide, but in comparison has only a fairly minimal risk of toxicity. I believe in the whole scientific literature there are only a couple of recorded deaths ascribed to bicalutamide - and those were older males with cancer.
There's quite a large number of trans girls taking bicalutamide now and I too am prescribed it by an endo.
Here is a link to the abstract from the first study of bicalutamide with trans girls - it has only just been recently published: https://imgur.com/a/rzy3Y.
However, the dose utilised in this study is too low to to act as a complete puberty blocker. For use as a puberty blocker the necessary dose has been calculated to be approx at least 150-200 mg/day for a trans girl close to first puberty, and who has T in typical mid male range for the age. However, for use as a puberty blocker (as opposed to use by trans women who are older), bicalutamide should still be considered somewhat 'experimental' - compared to say, cyproterone acetate.
But for trans women who are slightly older and whose T has already been significantly reduced to near female range, bicalutamide works very well at a dose of 50 mg/day or even 25 mg/day.
Also, because bicalutamide blocks DHT, it tends to both protect scalp hair, and assist with hirsutism too.