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#23909 - 06/19/05 01:31 AM Sirna Update
jme Offline


Registered: 06/18/05
Posts: 5
Hi everyone. I am a new poster and came across the topic of Sirna. I've done a little research on this topic and thought I would share a bit if anyone is interested.

Sirna is a publicly traded company on the stock exchange so if you were to go to say "yahoo" (I hope I can name another website) and go to their finance section and put in their ticker symbol (RNAI), you can read about the company and any news that is coming out about their work etc.

I've read a few posts regarding gene therapy and the dangers involved. siRNA (short interfering RNA) is not gene therapy per se. With gene therapy you are removing a defective gene and replacing with a non defective one or you are trying to fix the defective gene in some way shape or form. This is dangerous because of possible damage to other genes etc.

With siRNA technology (this is not something new. There are a number of biotech companies that are investigating different therapies from macular degeneration to huntingtons disease), you are not messing with the gene, you are only blocking the messenger RNA from making a certain protein.

I look at it this way. Take two people, and place them on opposite sides of a room. Person A has a flashlight which would represent the gene and the beam of light representing the messenger RNA. If person flashes a beam of light at person B it causes person B to react (which would represent the cell making a protein). If a piece of paper (representing siRNA) blocks the beam of light, the message does not get to where it needs to go. The flashlight (gene) has not been modified, its message just doesn't get to where it needs to go...ie, the protein is not made by the cell.

This product will be administered by a doctor. I believe the reason for this is simply liability. Some people have no problems reading the directions on the side of a prescription bottle...others do. Could you imagine if this was sold over the counter or even given out by prescription? I have heard stories of people going to a party, passing out and having friends nair their eyebrows. Well, I think you can see where I am going with this.

The product (Trichozyme)is suspended in an alcohol base which is then placed on the skin. I am guessing the alcohol helps with absorbtion in to the hair follicle a lot easier than a thick cream. Sirna has so far done in vitro and in vivo studies to prove the product makes it in to the hair follicle cells. This is very important. A major headache for siRNA researchers for other ailments has been the delivery mode. Cells do not readily take up RNA. When they have RNA knocking on their door they automatically "think" virus. This must not be a problem for this product.

From what I have read, they expect to start human trials in 2006 and will have a product for general public use by 2011.

I hope some of this was helpful. Again, this is just research I have done, so things could change.

jme

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#23910 - 06/20/05 04:45 AM Re: Sirna Update
md1239 Offline
Major Contributor

Registered: 01/14/05
Posts: 188
"From what I have read, they expect to start human trials in 2006 and will have a product for general public use by 2011."

Feel free to wait till 2011, then...


Edited by md1239 (06/20/05 04:45 AM)

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#23911 - 06/20/05 10:07 PM Re: Sirna Update
jme Offline


Registered: 06/18/05
Posts: 5
md,

5 to 6 years is not that long off. I was just updating the list on Sirna. This is hopefully going to be a viable option for those who have had little success with laser treatments or those that don't have the many hours needed to invest in something like electrolysis.

jme

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#23912 - 06/21/05 12:38 AM Re: Sirna Update
md1239 Offline
Major Contributor

Registered: 01/14/05
Posts: 188
In 5-6 years you could have any amount of hair removed permanently that you would like, without the help of any magical rub on cream.

Besides, even when/if something like this is developed, side effects of medications often don't show up for years. The side effects of today's permanent and long-term hair removal methods is well known because there are virtually zilch.

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#23913 - 06/21/05 01:26 AM Re: Sirna Update
dfahey Offline

Top 10 Contributor

Registered: 10/27/03
Posts: 9542
Loc: Columbus, Ohio
New drugs cost a huge fortune to develop. The average research and development costs for a new drug is about 800 million dollars. That's one of the reasons a new drug introduced to market costs so much more than the ones that have been around for years. Most drugs take ten years to get through the hoops of the FDA. An exception is cancer drugs. They don't cost as much on the research + development side because you can't really test them on non-cancerous patients - they go straightway to the ones that need to try something quickly. My point is, not only will this drug take time to get to the general public, but it will be very, very costly.

My other speculation is, if a doctor is needed to prescibe and administer it, will the turf wars start? If a doctor has a laser, for instance, will she/he advise the patient (who hasn't tried laser) to just have laser because they have had better results with laser for 8 years and the side effects of this new medicine are unknown? Laser therapy would bring more money than a mere office visit to administer the stuff. The pursuit of money always makes humans behave pathetically. If other non-laser doctors go ahead and prescibe and administer this medicine, then you would see the food fight start. It would threaten the laser physicians and the laser industry as a whole. I wouldn't be a bit surprised for the fierce lobbying to begin as to what medical specialty would have the privelege of dispensing this drug.

If I was as hairy as some explain they are, I'd try to find out if I could participate in the clinical trials, because this does sound like it is far from the reach of the general public.

Dee
_________________________
Dee Fahey, R.N., C.T.
Licensed by the State Medical Board of Ohio for Nursing license and Cosmetic Therapy/Electrolysis license
_____________________
ELECTROLYSIS FAQ'S:

British Institute & Association of Electrolysis

http://www.electrolysis.co.uk/?page_id=16

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#23914 - 06/21/05 02:11 AM Re: Sirna Update
jme Offline


Registered: 06/18/05
Posts: 5
I'm not sure I agree with you on the fighting between those physicians that use lasers and those that might use this new product. It's difficult to say how much Trichozyme will cost when it becomes available, but if it is more expensive than lasers, then there will always be a niche for lasers. We live in a free market society too. There have been numerous medications and treatments developed over the years that have fallen to the wayside because of better medications and treatments, that is just the way it goes.

Again, when I wrote the post, they stated a release of 2011. A lot of things can change between now and then, but the whole reason for my post was just to update previous posts on the subject.

Md,

You state that in 5 or 6 years you could have all the hair you wanted removed permanently. What about those that have tried laser over and over with little or no results? What about those that have no access to someone who performs electrolysis?

jme

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#23915 - 06/21/05 03:30 AM Re: Sirna Update
dfahey Offline

Top 10 Contributor

Registered: 10/27/03
Posts: 9542
Loc: Columbus, Ohio
jme, I forgot to tell you how wonderful your first post was about Trichozyme. I really liked the flashlight analogy. Thank you for telling us about this with such clarity. It is truly an exciting new developement and please post as often as you know anything new about the research.

Thanks,

Dee
_________________________
Dee Fahey, R.N., C.T.
Licensed by the State Medical Board of Ohio for Nursing license and Cosmetic Therapy/Electrolysis license
_____________________
ELECTROLYSIS FAQ'S:

British Institute & Association of Electrolysis

http://www.electrolysis.co.uk/?page_id=16

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#23916 - 06/22/05 12:29 PM Re: Sirna Update
md1239 Offline
Major Contributor

Registered: 01/14/05
Posts: 188
Quote:


Md,

You state that in 5 or 6 years you could have all the hair you wanted removed permanently. What about those that have tried laser over and over with little or no results? What about those that have no access to someone who performs electrolysis?

jme




Well I would suggest to those people that they either try another laser practitioner - perhaps someone more reputable - or to visit www.wrope.com or www.electrology.com to search for an electrologist closest to them. Some of those who are in desperate need of an electrologist without one near them can travel if they wish, instead of holding their breath for the possibility that maybe in 5-6 years there might just be a miracle medication to work. I could just be myopic though.

My point is, if this condition really strikes someone as an urgent "problem," there is no logic in waiting 5-6 years for something that could be a faint hope.

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#23917 - 07/09/05 10:07 PM Re: Sirna Update
jme Offline


Registered: 06/18/05
Posts: 5
Although this is not exactly related to the permanent hair removal product Sirna is developing, in a round about way it is.

Just recently, Sirna completed a private stock sale worth $28 million. This money will allow them to go ahead with their scheduled clinical trials that are about to start soon. Stage I trials for their hair removal product is scheduled for 2006. This is a very important step because clinical trials are very costly and it's even more difficult if you are a small biotech company. This will give them enough money to continue with all their planned trials for over 2 years.

jme

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#23918 - 07/25/05 09:41 PM Re: Sirna Update
jme Offline


Registered: 06/18/05
Posts: 5
Just an update on Sirna. Not exactly hair related but definitely good news that will trickle down to hair removal.

A study published in Nature Biotechnology shows the first demonstration that Sirna's technology works in patients.

In this study involving hepatitis B, there was a 95% reduction in the hepatitis B virus in patients.

jme

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