It did with me. 100 mg was not enough for me. Granted, I'm buying my Spiro from overseas. You get better quality assurance in the U.S.
Actually, lowering your dosage won't "induce" anything, it just may be less effective. But, it may be that 100 mg. is all YOU need. Give it a try. I say take the least amount possible. 100 mg. is still far better than none at all.