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#73613 - 05/02/10 04:52 AM Licorice extract interesting!!
roma18 Offline
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Registered: 09/20/06
Posts: 424
Loc: Bay Area, California

http://www.modernmedicine.com/modernmedi...ategoryId=40160


Frankfurt, Germany — A study using glycyrrhizic acid, the herbal extract from licorice, proves to be effective in halting hair growth in rats. This topical approach appears to be promising for future epilation therapies, and may rival currently used epilation modalities, which can frequently be associated with a host of unwanted side effects.

In the experiment, 15 percent glycyrrhizic acid was dissolved in an aqueous solution containing 10 percent urea and 20 percent ethanol at 80 degrees Celsius. The solution was cooled down to 40 degrees and topically applied to the back of the neck of Wistar rats twice a day for two weeks followed by four weeks without treatment for a total of two years. Histological analysis, scanning electron microscopy as well as in situ TUNEL assay were performed evaluating treatment outcomes.

Experiment outcome

Results showed that hair loss was visible as early as three days after the first treatment application of the solution, and after six to 12 days of treatment, the targeted skin was nearly free of hairs without any sign of skin irritation or other unwanted side effects.

The histology of the hair follicles and scanning electron microscopy of hairs showed damage to the anchoring structures of the hair cuticle and a detachment of the hair shaft from the follicular wall. Also, the in situ TUNEL assay showed apoptotic cells in the bulge region after treatment with glycyrrhizic acid.

“Though we noticed that the hairs began to grow again after each treatment, the hair shafts were thinner, the hair density per skin area was decreased and we were able to achieve a permanent reduction in re-growing hair quantity by more than 50 percent,” says August Bernd, Ph.D., professor of the department of dermatology and venerology, University Hospital, J. W. Goethe University, Frankfurt/Main, Germany, and co-author of the study. “Even after a periodically long-term treatment for the one year we evaluated, we did not see any abnormalities of the skin surface at the target areas nor any dysplastic changes in the histology.”

Glycyrrhizic acid is an herbal extract commonly used in traditional Asian medicine and appears to be responsible for the epilatory effect seen. Liqorice has a known anti-androgenic effect and inhibits alpha five reductase and androgen receptors.

Potential for treatment

The topical treatment with glycyrrhizic acid shows much promise as a quick, safe and effective method for hair removal and, according to Dr. Bernd, there do not appear to be any disadvantages with this therapy. The underlying mechanism of action of glycyrrhizic acid on hair removal is still unknown and clinical trials are the next step, Dr. Bernd says.

“Current hair removal approaches such as topical creams and laser treatments are variably effective and can be associated with a slew of unwanted side effects, including pain, skin irritation, contact eczema, folliculitis and hyperpigmentation.

“The topical treatment with glycyrrhizic acid showed to be effective in achieving a quick and painless method for hair removal and glycyrrhizic acid is at least a candidate molecule for the development of a new promising epilating drug which very well may rival currently used hair removal approaches,” Dr. Bernd says.

Disclosures: At the beginning of the study Dr. Bernd and his colleagues received some support from the German Academic Exchange Service, but later financed the study with their own budget.
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#73615 - 05/02/10 06:05 AM Re: Licorice extract interesting!! [Re: roma18]
MagicalPrincessKitty Offline
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Registered: 09/01/09
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Loc: California
Wow, totally interesting... Thanks for the head's up Roma!
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#75925 - 06/25/10 04:07 AM Re: Licorice extract interesting!! [Re: MagicalPrincessKitty]
J M Offline
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Registered: 06/10/04
Posts: 35
This is so intriguing and so simple that I am tempted to run some experiments myself. I am pricing an order of glycyrrhizic acid so I can try to reproduce this experiment*. Anyone want in on my order?

The most intriguing thing is that this has the potential to hit the market without FDA regulation.


*remember, one of the two thing that "makes science science" is that it is repeatable. Do the same experiment and you should get the same result.

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#75926 - 06/25/10 05:23 AM Re: Licorice extract interesting!! [Re: J M]
MagicalPrincessKitty Offline
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Registered: 09/01/09
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Loc: California
I'd be tempted too! I think you should duplicate the aqueous solution as well since it's a pretty simple one. Applying it to your skin without diluting it may cause irritation or some other side effect.

Tell you what, if you try it and report your results, I will be guinea pig number two. I'm not up for trying it yet, because I'd want to do more research. But it seems simple enough, and I am a big proponent of doing research on the species you are trying to benefit (in other words, human testing, not animal testing). Sure, something can go wrong, but at least a human can consent and is capable of knowing the risks.

So yeah, I say give it a try. Be really careful!
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6.75 hrs electrolysis on tummy starting 01/07/10 (Apilus Platinum, picoflash)
10 hrs electrolysis on arms starting 01/30/10 (Apilus Platinum, synchro/picoflash)
37.25 hrs DIY electrolysis on left arm (OneTouch and Instantron)
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#75927 - 06/25/10 06:22 AM Re: Licorice extract interesting!! [Re: MagicalPrincessKitty]
emilily Offline
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Registered: 03/20/10
Posts: 367
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I wouldn't recommend it. Though it's found in licorice naturally and used by the Japanese as a sweetner, most countries recommend people limit their intake to the acid to 100mg per day (50g licorice) or in the case of Japan, 200mg per day. While you're not ingesting it, even using it topically could have adverse side effects.

Here is the abstract of one of the articles I found;

Food and Chemical Toxicology
Volume 31, Issue 4, April 1993, Pages 303-312
doi:10.1016/0278-6915(93)90080-I |
Copyright © 1993 Published by Elsevier Ltd.
Permissions & Reprints
Review section
Glycyrrhizic acid in liquorice—Evaluation of health hazard

F.C. Størmer*, R. Reistad† and J. Alexander*

†National Institute for Consumer Research, PO Box 173, 1324 Lysaker, Norway

*National Institute of Public Health, 0462 Oslo Norway
Accepted 17 December 1992.
Available online 21 November 2002.

Abstract

Literature on case reports, clinical studies and biochemical mechanisms of the sweet-tasting compound glycyrrhizic acid in liquorice was critically reviewed to provide a safety assessment of its presence in liquorice sweets. A high intake of liquorice can cause hypermineralocorticoidism with sodium retention and potassium loss, oedema, increased blood pressure and depression of the renin-angiotensin-aldosterone system. As a consequence, a number of other clinical symptoms have also been observed. Glycyrrhizic acid is hydrolysed in the intestine to the pharmacologically active compound glycyrrhetic acid, which inhibits the enzyme 11β-hydroxysteroid dehydrogenase (in the direction of cortisol to cortisone) as well as some other enzymes involved in the metabolism of corticosteroids. Inhibition of 11β-hydroxysteroid dehydrogenase leads to increased cortisol levels in the kidneys and in other mineralocorticoid-selective tissues. Since cortisol, which occurs in much larger amounts than aldosterone, binds with the same affinity as aldosterone to the mineralocorticoid receptor, the result is a hypermineralocorticoid effect of cortisol. The inhibitory effect on 11β-hydroxysteroid dehydrogenase is reversible; however, the compensatory physiological mechanisms following hypermineralocorticoidism (e.g. depression of the renin-angiotensin system) may last several months. It is not possible, on the basis of existing data, to determine precisely the minimum level of glycyrrhizic acid required to produce the described symptoms. There is apparently a great individual variation in the susceptibility to glycyrrhizic acid. In the most sensitive individuals a regular daily intake of no more than about 100 mg glycyrrhizic acid, which corresponds to 50 g liquorice sweets (assuming a content of 0.2% glycyrrhizic acid), seems to be enough to produce adverse effects. Most individuals who consume 400 mg glycyrrhizic acid daily experience adverse effects. Considering that a regular intake of 100 mg glycyrrhizic acid/day is the lowest-observed-adverse-effect level and using a safety factor of 10, a daily intake of 10 mg glycyrrhizic acid would represent a safe dose for most healthy adults. A daily intake of 1–10 mg glycyrrhizic acid/person has been estimated for several countries. However, an uneven consumption pattern suggests that a considerable number of individuals who consume large amounts of liquorice sweets are exposed to the risk of developing adverse effects.

Abbreviations: LOAEL = lowest-observed-adverse-effect level; NOAEL = no-observed-adverse-effect level
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#75928 - 06/25/10 08:39 AM Re: Licorice extract interesting!! [Re: emilily]
MagicalPrincessKitty Offline
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Registered: 09/01/09
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Loc: California
Potassium loss, eh? Hey, maybe it will counter-act the potassium retention some people struggle with while on spiro for hirsutism! :P
_________________________
3.5 laser sessions on lower legs starting 09/24/09 (GentleLASE)
3 laser sessions on bikini starting 01/15/10 (GentleLASE)
1 laser session on underarms starting 07/02/10 (GentleLASE)
1 laser session on right arm starting 07/02/10 (GenteLASE)
6.75 hrs electrolysis on tummy starting 01/07/10 (Apilus Platinum, picoflash)
10 hrs electrolysis on arms starting 01/30/10 (Apilus Platinum, synchro/picoflash)
37.25 hrs DIY electrolysis on left arm (OneTouch and Instantron)
1.75 hrs DIY electrolysis on tummy (Instantron, thermolysis)

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#75931 - 06/25/10 12:35 PM Re: Licorice extract interesting!! [Re: J M]
jr98118 Offline
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Registered: 01/20/10
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Loc: pittsburgh, pa
I want in on your order!

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#75935 - 06/25/10 02:24 PM Re: Licorice extract interesting!! [Re: jr98118]
J M Offline
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Registered: 06/10/04
Posts: 35
"most countries recommend people limit their intake to the acid to 100mg per day (50g licorice) or in the case of Japan, 200mg per day. While you're not ingesting it"

The thing is that in a 15% solution, assuming that you were applying it to a small area, you would use like 1-2ml of solution per day and it would be well within the recommended oral intake limit. the published experiment summary states that the solution was applied on for two weeks and off for four weeks. So total six week consumption was much lower.

Costs are generally around $250-300 / 500g. I'll break it into 100g quantities and provide an equal amount of urea for ~$75 (or less depending on the best deal I can find a lower price or if I have enough interest to order 1kg) shipped to you in the United States. That should be plenty for running some experiments on your dog, cat, lab mice, goat, or even a small patch on yourself. (it would make 2/3 liter of solution) If it works as you expect, I would suggest mixing up some in varying strengths and doing concurrent tests on different patches to find the most effective and safest concentrations.

I do not know how stable the mixture is. Maybe it should be refrigerated. Maybe that would lower the solubility and cause the solvent to settle out. I don't know. Maybe you could use isopropal alcohol instead. I don't know.



I imagine that the glycyrrhizic acid and urea can be dissolved in a lotion type of solute like drugs like benzoyl peroxide (an oxidant)often are. But that is for a later time. If this works well, I throw this to my technology incubator for further experiments, determining FDA regulation status, and finding a better solute carrier for the active ingredients. But that would be months away.

I am an electrical engineer, not a chemical engineer. I did take my fair share of chemistry in school, but a lot of the organic chemistry is outside of my realm of knowledge. But I did stay at a holiday in express.

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#76105 - 06/30/10 04:52 AM Re: Licorice extract interesting!! [Re: J M]
MagicalPrincessKitty Offline
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Registered: 09/01/09
Posts: 897
Loc: California
Please nobody do this on their pet. You're the one who wants to be hairless, not them. They can't consent, and to be honest you don't know what dosages are safe for random pets vs much larger humans. Besides, if it works, do you really want a bald spot on your dog?
_________________________
3.5 laser sessions on lower legs starting 09/24/09 (GentleLASE)
3 laser sessions on bikini starting 01/15/10 (GentleLASE)
1 laser session on underarms starting 07/02/10 (GentleLASE)
1 laser session on right arm starting 07/02/10 (GenteLASE)
6.75 hrs electrolysis on tummy starting 01/07/10 (Apilus Platinum, picoflash)
10 hrs electrolysis on arms starting 01/30/10 (Apilus Platinum, synchro/picoflash)
37.25 hrs DIY electrolysis on left arm (OneTouch and Instantron)
1.75 hrs DIY electrolysis on tummy (Instantron, thermolysis)

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#76239 - 07/04/10 05:47 AM Re: Licorice extract interesting!! [Re: J M]
werty Offline
Member

Registered: 10/22/08
Posts: 4
I thought about doing this also, but the price was way too expensive for just me. If you do this, I would like to be in.

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#77665 - 08/07/10 05:57 PM Re: Licorice extract interesting!! [Re: werty]
horo Offline
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Registered: 08/07/10
Posts: 13
Did anyone tried this? Is it effective?
I already bought glyzyrrhizic acid 75% dissolved it in hot water and when it cooled down it turned into a jelly.
I started applying it to my skin yesterday, I have had 4 treatments already, no side effects so far. But it did not remove a single hair, I guess I will have to be patient.
If anyone has tried glycyrrhizic acid as hair removal, please share your experience

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#77669 - 08/07/10 11:58 PM Re: Licorice extract interesting!! [Re: horo]
dfahey Offline

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Posts: 9438
Loc: Columbus, Ohio
Another reminder: This ingredient, which is found in licorice, can cause side effects such as increased blood pressure and edema. It can disrupt the balance of the corticosteroids as well.
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#77683 - 08/09/10 04:56 AM Re: Licorice extract interesting!! [Re: horo]
jonas Offline
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Registered: 07/05/10
Posts: 6
Loc: Atlanta, GA
You bought glyzyrrhizic acid or powdered licorice extract that supposedly has 75% glyzyrrhizic acid?

In any case, glyzyrrhizic acid is supposedly not very soluble in water, which is why most extractions use a different solvent, perhaps a 30%/70% ethanol / water mixture.

I'm a but skeptical about the glyzyrrhizic acid content of some products. For example, this one claims 98% for $14 per 30g. But if you buy the chemical from a chemical supply at the same purity level, it's hundreds of dollars for a few milligrams. And the methods of concentrating the acid are not easy or cheap.

There is a thread here in polish where people describe their experiences with this brew. Mixed results, but it doesn't seem like many of them know what they're doing.

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#77684 - 08/09/10 07:15 AM Re: Licorice extract interesting!! [Re: jonas]
horo Offline
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Registered: 08/07/10
Posts: 13
Regarding the purity of the glycyrrhizic acid as far as I know there are two methods for analyzing - HPLC and UV.
If you buy 98% HPLC - this mean that you have almost 100% pure acid. I bought 98% UV - which mean that the purity of the acid is approximately 74-75 %.
I'm from Eastern Europe and managed to find some chemical compound supplier in Europe, but they were unwilling to sell small quantities, beside the price was very very high.
All these European suppliers buy glycyrrhizic acid from China manufacturers, so I contacted as many Chinese manufacturers as possible and ask them for quotations. Some of them offered me prices of 350 usd for 0.200 kg, but most of them gave me prices of 120 usd (including shipping). So I bought 200 g 98% UV- it is white powder and according to the information in the internet you can dissolve it either in hot water or in ethanol.
I'm dissolving it in hot water and when it cool down it turn into a jelly. When you apply this jelly to your skin it is a bit sticky.
Thanks for the polish forum link. As I don't speak polish I used google to translate it, still I'm not sure I got the meaning of most of the posts. But I think that some of the forumers explain that the acid actually do not irritate their skin which I can confirm.
This is a third day since I started treating my skin with glycyrrhizic acid and again not a single hair has been removed. One girl in Polish forum says that she has used the acid after epilation and the hair growth had been reduced with 30% if I had understood correctly. I will try this too, I will report results later.
Regards

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#77686 - 08/09/10 12:23 PM Re: Licorice extract interesting!! [Re: horo]
Arlene R. Batz, CPE Offline

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Registered: 01/14/05
Posts: 1144
Loc: New York City - Queens
It would be very interesting to see what your results are. We have been using glycyrrhizic acid in skin care for years on people with hyperpigmentation because it inhibits melanin synthesis and so far, we have not seen any change in hair growth in areas where electrolysis is not being done. Darkened skin lightens but we haven't even noticed any effect on the pigment of hair.

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#80645 - 12/01/10 02:34 AM Re: Licorice extract interesting!! [Re: werty]
keniacrz21 Offline
Member

Registered: 04/11/10
Posts: 8
If it works without any side effect let me know then I'll try.

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#81675 - 01/07/11 09:26 PM Re: Licorice extract interesting!! [Re: keniacrz21]
ahto Offline
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Registered: 09/18/09
Posts: 2
has anyone tryed yet?

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#89020 - 06/23/11 07:09 AM Re: Licorice extract interesting!! [Re: ahto]
horo Offline
Contributor

Registered: 08/07/10
Posts: 13
Yes, I tried it. It works !!!!!!!
But you have to remove the hairs from the roots and apply it regularily.
Beside it made my skin on the face beautiful, before I started using the acid it was sooooo oily.
I'm buying my glycyrrhizic acid from ebay.

http://cgi.ebay.co.uk/ws/eBayISAPI.dll?ViewItem&item=180686207309&ssPageName=STRK:MESELX:IT#ht_500wt_949


Edited by horo (06/23/11 07:13 AM)

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#90144 - 07/22/11 07:52 AM Re: Licorice extract interesting!! [Re: horo]
Swoosh Offline
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Registered: 07/15/06
Posts: 1
Horo -

When you say "it works", to what extent? Like percentage wise how much less hair would you say you have now and how long have you used the product for?

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#115781 - 10/08/14 02:35 PM Re: Licorice extract interesting!! [Re: Swoosh]
jonas Offline
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Registered: 07/05/10
Posts: 6
Loc: Atlanta, GA
Apologies for resurrecting a dead thread, but I found it interesting that some newer papers appear to have duplicated results documented in the original article(s). For example: Topically applied glycyrrhzic acid causes hair removal in rats. At first, I thought this was just a rehash of the original research, but it looks like the authors, location, and other details are different. Unfortunately, according to the article regrowth after long-term use was only reduced by about 20%, which might be hard to even notice unless used somewhere like the scalp.

I tried mixing up some glycyyhzic acid in a solution of ethanol a while back, but ended up with something that was unusable because it was as hard as a rock at room temperature. Perhaps the ammonium salt would be a more suitable component.

One of the kind of interesting things about the latest report is that the solution was applied with a toothbrush. Although this doesn't explicitly state that hair didn't need to be epilated first, it suggests perhaps an easier method of application than has been tried before.

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#115783 - 10/08/14 06:15 PM Re: Licorice extract interesting!! [Re: jonas]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
Quotes from the article and my comments:

>Article: "Interestingly, long-term treatment reduced the regrowth of hair of about 20%."

QUESTION: "Long term" is used to describe the TREATMENT; not the "long term RESULTS." A quick read, and you get the wrong idea.

So, for how long did they maintain the 20% reduction? Six months, 2-years? I suppose they are saying you have to continue using the solution ceaselessly? What happens once you stop? (Oh, I know ... it all grows back!)


>Article: "Examination by scanning electron microscopy showed a smoothed hair cuticle that might facilitate detachment of the hair shaft from the follicular wall."

COMMENT: Detachment of the hair shaft has nothing to do with any effect on the follicle. It's the follicle that grows the hair. The hair is essentially dead tissue.

If you are looking for permanent hair removal (or reduction) this ain't gonna do it. There are specific reasons why no rub-on is ever going to remove a hair permanently. Not happening ... Stop looking for the "easy fix!" (Unless, of course, you want to buy it from me.)

Recommendation: EAT the licorice (a "Droopja" if you can find it. Yum ...)

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#115784 - 10/09/14 01:11 AM Re: Licorice extract interesting!! [Re: Michael Bono]
jonas Offline
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Registered: 07/05/10
Posts: 6
Loc: Atlanta, GA
Originally Posted By: Michael Bono
Quotes from the article and my comments:

Recommendation: EAT the licorice (a "Droopja" if you can find it. Yum ...)


That might help, because eating relatively small amounts of licorice can almost half the serum testosterone in men. It can also raise blood pressure substantially and is thought to effect estrogen receptors more strongly than estradiol. Not a good food to consume for most men.

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#115786 - 10/09/14 09:24 AM Re: Licorice extract interesting!! [Re: jonas]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
Good for you ... Bad for you

If you've "been around" long enough, like me, you realize (if you wait long enough) that the foods and supplements that were "bad for you" suddenly become "good for you" ... but then might become "bad for you again!" It can drive you crazy.

Vitamin E ... good for you, now bad for you. Vitamin D ... bad for you, now good again. EGGS ... very bad; but now okay and good. Red Meat ... the worst ever ... but now (good in appropriate doses). Vitamin C ... in mega-doses? Same deal.

Butter ... BAD ... margarine better. Oooops, now just the reverse. Eat more tuna and salmon (for low-T), but watch out for the mercury; bad. Coffee ... BAD ... now good to prevent Alzheimer's ... but, wait ... maybe not so good again (other problems).

What the hell am I saying?

Bottom line: if you are looking for a FOOD to remove (or reduce your hair growth) it's probably not going to happen. Eating licorice is "lovely" ... but chances are it will do ZIP for your hair problems.

Same with any lotion ... NOT happening. (Add in here the ridiculous "home devices.") Still, people will try the quick (inexpensive) fixes in a futile attempt that "food or supplements" ... or some lotion or "painless home unit" ... will help. It won't!

You're just wasting your time; just "pissing in the wind." Get to the REAL procedures that actually work.

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#115787 - 10/09/14 01:48 PM Re: Licorice extract interesting!! [Re: Michael Bono]
Helen1983 Offline
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Registered: 08/28/13
Posts: 300
Natural black licorice is what I eat love the stuff lol I read a long time ago licorice is good at reducing facial hair, stop taking it though and the effects wear off.

I eat it because I enjoy it, however not in large amounts just as a treat. Too much Licorice is not good and can thin you blood do not start taking licorice in large amounts if bad for anyone in large quantities and especially if you have a heart issue or close family members who have.

Licorice may help but any effects from it will only be minimal so don't hold it out to be the ultimate cure.


Edited by Helen1983 (10/09/14 02:11 PM)

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#115985 - 10/28/14 02:05 AM Re: Licorice extract interesting!! [Re: Helen1983]
jonas Offline
Member

Registered: 07/05/10
Posts: 6
Loc: Atlanta, GA
Found the whole article (w/ pics) here:
Topically applied glycyrrhizic acid causes hair removal in rats

The electron microscope pictures of the control and experiment hair cuticle is very interesting, and the epilation effect on the rats is pretty impressive. The article's authors speculate that the epilation effect could be caused either by β-1 integrin metabolism changes in the presence of glycyrrhizic acid or by an anti-steroid effect in follicle cells which are known to be sensitive to sex steroids.

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#115987 - 10/28/14 08:35 AM Re: Licorice extract interesting!! [Re: werty]
Proudmoore Offline
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Registered: 10/24/14
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Loc: Chicago, IL
Would it be better to just read around on the web than try on yourself or - even worse - try on your pet? It's a fairly new study so do you really want to be test subject? What if it makes you feel bad? Or else, what is it burns you? Is it really worth it? I suggest waiting and let more tests to be conducted.

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#115989 - 10/28/14 09:15 AM Re: Licorice extract interesting!! [Re: Proudmoore]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA

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#115990 - 10/28/14 09:16 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA

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#115991 - 10/28/14 09:16 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
DAMN HAIRTELL!

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#115992 - 10/28/14 09:17 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA

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#115993 - 10/28/14 09:18 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Posts: 3052
Loc: Santa Barbara, CA USA

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#115994 - 10/28/14 09:18 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
Time to just GIVE UP!

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#115995 - 10/28/14 09:25 AM Re: Licorice extract interesting!! [Re: Proudmoore]
jonas Offline
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Registered: 07/05/10
Posts: 6
Loc: Atlanta, GA
Originally Posted By: Proudmoore
Would it be better to just read around on the web than try on yourself or - even worse - try on your pet? It's a fairly new study so do you really want to be test subject? What if it makes you feel bad? Or else, what is it burns you? Is it really worth it? I suggest waiting and let more tests to be conducted.


It's interesting research that's all. I'm not proposing that anyone try it on themselves or their pet. Certainly, there are major differences in hair growth cycles between humans and rats, but I thought the point of this place was to discuss new or promising developments.

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#115997 - 10/28/14 09:56 AM Re: Licorice extract interesting!! [Re: jonas]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
Okay, one last try at this!

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#115998 - 10/28/14 09:56 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
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#115999 - 10/28/14 09:56 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
Perfect ... just perfect!

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#116000 - 10/28/14 10:11 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA

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#116001 - 10/28/14 10:12 AM Re: Licorice extract interesting!! [Re: Michael Bono]
Michael Bono Online

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Registered: 01/11/11
Posts: 3052
Loc: Santa Barbara, CA USA
just not happening ... tried everything. Gave up. Y'all need to fix this site or just be limited to a sentence here and there.

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